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Professor Yun Jae-sook and Her Research Team Develop Alkylation Reaction of Alkenes Using Chiral Catalyst


Professor Yun Jae-sook and Dr. Jang Won-jun (skku.edu)

On March 4th, Professor of the Department of Chemistry, Yun Jae-sook, and her research team revealed that they had developed an effective synthesis method, using chiral alkyl boron compounds through transition metal catalysis. Chiral alkyl boron compounds are known as useful synthetic intermediates used in various fields such as natural products and medicines. Many synthesizing chiral alkyl boron compounds research conducted until recently had limitations. That research used expensive chiral auxiliaries and produced a large amount of metal waste. However, asymmetric carbon-carbon conjugate addition using olefin, which Yun’s research team developed, overcame the limitations. The use of olefin, a compound made up of hydrogen and carbon that can be easily found, allowed for high yield and selective synthesis of chiral alkyl boron compounds. Moreover, the research team proved its utility by efficiently synthesizing natural products such as phaseolinic acid and other derivatives. This method can transform carbon-boron bonds in various ways. It is expected to be a useful synthesis tool for synthesizing medicines and physiologically active substances. This research was published in the world-renowned chemistry journal, Angewandte Chemie International Edition (ACIE), on February 23rd.

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