|Jeong Meong-Ho / skku.edu|
|Kim Hyun-Ji / skku.edu|
Professor Kang Jong-Sun’s research team from SKKU’s School of Medicine has investigated a new molecular mechanism related to heart fibrosis that occurs after a sudden heart attack, and in cardiac disorders. The research team has found a new mechanism that can prevent cardiac disorder, and can develop heart functionality. The research was led by the SKKU School of Medicine and included Jeong Myeong-Ho (from Professor Kang Jong-Sun’s Molecule Cell Biology class), and Jeong MeongHo (from Professor Jo Hanna’s Physiology class). The research team has assumed that the Wnt neuro-transmission system which participates in the fibrosis process increases in mice that are deprived of Cdon (polyfunctional acceptor). Wnt neurons are essential to structural development, regeneration, and the controlling activation of various stem cells. Also, when Wnt activates abnormally, it can contribute to accelerating tissue fibrosis in the aging process. Therefore, deprivation of Cdon has the possibility of occurring over the signal, leading to Myocardial (heart muscle) injury. During the research, the team identified that Wnt neuron increases, and activates b-catenin when Cdon DNA was deprived, therefore increasing the occurrence of DNA participating in heart fibrosis. Moreover, in Cdon deprived cardiac muscle cells and the heart, an abnormal occurrence of proteins, and intracellular malposition were detected. This research implies that Cdon DNA plays a significantly important role in restraining Wnt neurons, and controlling the remodeling constancy of the heart muscle. The molecular mechanism, the SKKU research team investigated, is expected to be applied to explain, and to diagnose the cause of genetic brain development deference. The research was published in the Proceedings of the National Academy of Sciences on February 2.
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